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Raised EosinophilsHealth Screening & Tests

Raised eosinophils, or eosinophilia, is characterized by an increased number of eosinophils in the bloodstream. Eosinophils are a type of white blood cell that are primarily involved in the body’s immune response, especially in relation to parasitic infections and allergic reactions.

Causes of Raised Eosinophils in Humans:
  1. Allergic Disorders: Conditions like asthma, allergic rhinitis, and eczema can lead to elevated eosinophil levels due to the body’s allergic response.
  2. Parasitic Infections: Eosinophils play a significant role in combating parasitic infections, such as those caused by roundworms, hookworms, and other helminths.
  3. Autoimmune Diseases: Disorders such as lupus and certain types of vasculitis can result in eosinophilia as the body mistakenly attacks its own tissues.
  4. Certain Cancers: Blood cancers, particularly certain types of leukemia and lymphoma, are associated with increased eosinophil counts.
  5. Medications: Some drugs, including certain antibiotics and anti-seizure medications, can cause eosinophilia as a side effect.
  6. Other Conditions: Conditions like Addison’s disease and certain skin disorders can also lead to raised eosinophil levels.
Diagnosis and Management:
  • Blood Tests: A complete blood count (CBC) with differential is used to detect elevated eosinophil levels.
  • Identifying the Cause: Treatment involves addressing the underlying cause of eosinophilia. This may include treating infections, managing allergies, or adjusting medications.
  • Monitoring: Regular monitoring may be necessary for chronic conditions associated with eosinophilia.
References:
  1. Rothenberg ME. “Eosinophilia.” New England Journal of Medicine, 1998; 338:1592-1600.
  2. Simon HU, et al. “Eosinophils: Biological Properties and Role in Health and Disease.” Nature Reviews Immunology, 2010; 10:573-587.
  3. Weller PF, et al. “The Pathophysiology of Eosinophilia.” Annual Review of Medicine, 1994; 45:289-299.

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